Pharmacokinetics of Coadministration of Guanfacine Extended Release and Methylphenidate Extended Release
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics of Coadministration of Guanfacine Extended Release and Methylphenidate Extended Release
BACKGROUND α2-Adrenoceptor agonists are used adjunctively to psychostimulants in treating attention-deficit/hyperactivity disorder (ADHD) when psychostimulants alone do not sufficiently reduce symptoms. However, data on the pharmacokinetic profiles and safety of combination treatments in ADHD are needed. OBJECTIVE The primary objective of this study was to evaluate the pharmacokinetic profile...
متن کاملPharmacokinetics of Coadministered Guanfacine Extended Release and Lisdexamfetamine Dimesylate
BACKGROUND In clinical practice, α₂-adrenoceptor agonists have been adjunctively administered with psychostimulants for the treatment of attention-deficit/hyperactivity disorder (ADHD). Two studies have examined the adjunctive use of guanfacine extended release (GXR, Intuniv®; Shire Development LLC, Wayne, PA, USA) with psychostimulants in children and adolescents with a suboptimal response to ...
متن کاملMethylphenidate. An update on extended-release formulations.
Methylphenidate remains the mainstay of pharmacological management in attention deficit hyperactivity disorder (ADHD). Despite having been available for over half a century, methylphenidates original formulation has been modified with the main purpose of extending its duration of action. This article will present a brief review of how these new formulations vary and how these should be selected...
متن کاملPreparation of Alprazolam Extended- Release Tablets and In vitro Characterization
Abstract The main aim of this study was to prepare and evaluate the extended - release system of an anxiolytic substance. Alprazolam is a short-acting benzodiazepine with general properties similar to those of diazepam. Our studies focused on the development of extended drug delivery system based on Hydroxy Propyl Methyl Cellulose (HPMC 4000cps) as retard agent and polyvinylpyrrolidone (PVP k30...
متن کاملGuanfacine Extended Release: A New Pharmacological Treatment Option in Europe
Children/adolescents with attention-deficit/hyperactivity disorder (ADHD) may have a poor or inadequate response to psychostimulants or be unable to tolerate their side-effects; furthermore, stimulants may be inappropriate because of co-existing conditions. Only one non-stimulant ADHD pharmacotherapy, the noradrenaline transporter inhibitor atomoxetine, is currently approved for use in Europe. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Drugs in R&D
سال: 2013
ISSN: 1174-5886,1179-6901
DOI: 10.1007/s40268-013-0009-5